Machine-assisted translation — the German original version is authoritative.
Metabolism & Weight
AOD-9604
HGH-Fragment 176-191 · Anti-Obesity Drug 9604
AOD-9604 is a modified fragment of the C-terminus (amino acids 176–191) of human growth hormone. It was investigated as a potential agent against obesity, but did not reach the targeted efficacy goals in clinical studies and was not approved as a medicine.
Regulatory status
Not approved for humans
Not approved as a medicine — efficacy for weight loss not established.
Drug class
Fragment of human growth hormone (HGH 176-191)
Half-life (informative)
Short; robust human data limited.
Studied in the literature
In clinical studies subcutaneous. No approval as a medicine.
Mechanism of action
The fragment is intended to reproduce the fat-reducing (lipolytic) properties of growth hormone and to inhibit the formation of new fat (lipogenesis) — according to the hypothesis without the growth-promoting effects (IGF-1) and without substantially affecting blood glucose. However, clinical confirmation of a relevant weight effect in humans was not forthcoming.
"Investigated" here expressly does not mean "proven effective" — the phase studies do not support an approved weight-loss benefit.
Research history
Developed by Metabolic Pharmaceuticals (Australia). In clinical studies on obesity, AOD-9604 missed the primary efficacy endpoints; approval as a weight-loss medication did not follow. Later it appeared in individual jurisdictions in dietary supplement/cosmetic contexts — regulatorily inconsistent.
Regulatory status by region
Clinically investigated, but without approval as a weight-loss medication. Regulatory status in supplement/cosmetic contexts inconsistent.
Research areas
- Obesity/lipolysis (clinically investigated, without approval)
- Metabolic research
Documented effects (from the literature)
- In studies it was predominantly described as well tolerated, without substantial changes in blood glucose.
- A clear, clinically relevant weight effect was not established.
Safety concerns & caution
- Lack of proof of efficacy as a weight-loss medication.
- Long-term safety outside of the studies not established.
Risks of gray-market purchase
- Marketed as a "research peptide" or in supplements; quality and content unassured.
- Marketing promises often go beyond the actual body of study data.
Frequently asked questions
Does AOD-9604 work for weight loss?
The clinical studies do not support an approved weight benefit — the primary efficacy goals were not met. It is not an approved weight-loss medication.
Is it the same as growth hormone?
No. It is only a short fragment of the HGH molecule and is intended to reproduce specific individual effects — not to replace the complete hormone.
Sources
Primary and reference sources for your own reading.
Related substances
Unfamiliar terms? Look them up in the glossary or read the fundamentals.
This profile is for information and education only. It is not medical advice and deliberately contains no dosing or usage details. Decisions about use belong in a doctor’s hands.