Machine-assisted translation — the German original version is authoritative.
Metabolism & Weight
5-Amino-1MQ
5-Amino-1-Methylquinolinium · NNMT-Inhibitor
5-Amino-1MQ is, strictly speaking, not a peptide but a small molecule (a quinolinium derivative) that inhibits the enzyme nicotinamide N-methyltransferase (NNMT). In fat cells, NNMT controls methyl and NAD metabolism; inhibition increased energy expenditure in mice and reduced body fat — without changing food intake. Published human studies are lacking, and it is not approved.
Regulatory status
Not approved for humans
Not approved; a preclinical research substance without human studies.
Drug class
Small-molecule NNMT inhibitor (not a peptide)
Half-life (informative)
Not well characterized (taken up orally in animal studies).
Studied in the literature
In animal studies systemically or orally.
Mechanism of action
5-Amino-1MQ inhibits NNMT and thereby lowers the consumption of S-adenosylmethionine (SAM) and nicotinamide in the fat cells. In models, this shifts energy metabolism toward fat oxidation and higher energy expenditure.
The evidence is preclinical; there are no published human studies.
Research history
5-Amino-1MQ stems from NNMT inhibitor research of the 2010s on obesity and metabolism and was investigated preclinically in rodent models.
Regulatory status by region
No approval for human use.
Research areas
- Obesity and body fat (preclinical)
- Metabolism and NAD biology
- Muscle aging (research)
Documented effects (from the literature)
- In mice, weight and fat reduction without overt acute toxicity.
- Human safety is unknown.
Safety concerns & caution
- NNMT/NAD metabolism has broad effects — long-term and off-target effects in humans are unclear.
- There are no clinical safety data.
Risks of gray-market purchase
- Marketed as a "fat-loss peptide", although it is not a peptide and no human data exist.
- Purity and identity are untested.
Frequently asked questions
Is 5-Amino-1MQ a peptide?
No — it is a small molecule (an NNMT inhibitor), but it is frequently marketed together with peptides.
Is there evidence in humans?
So far only cell and animal data; published human studies are lacking.
Sources
Primary and reference sources for your own reading.
Related substances
Unfamiliar terms? Look them up in the glossary or read the fundamentals.
This profile is for information and education only. It is not medical advice and deliberately contains no dosing or usage details. Decisions about use belong in a doctor’s hands.